More than 11,000 lives have been lost in Turkey and Syria, and the death toll is expected to rise after a powerful earthquake on Monday. Many more people are injured and homeless.
Rescuers have been racing against time to work through the rubble, but the cold weather and fuel and truck shortages have complicated the efforts. Dozens of countries are sending aid-and-rescue teams to the region.
Here are some pictures and video showing the aftermath of the disaster.
This gallery contains graphic images.
Rescuers carrying Mehtez Farac, 8, a Syrian survivor who was pulled from the rubble after the earthquake, in Hatay, Turkey.
Turkish military members removing the rubble from a collapsed house in Iskenderun, Turkey.
Rescuers holding Kerem Agirtas, a baby boy who was pulled from under the rubble in Hatay, Turkey.
Rescue workers carrying Mahmut Avami, a Syrian, at the site of a collapsed building more than 50 hours after the earthquake struck, in Hatay, Turkey.
Rescuers searching for survivors amid the rubble of a collapsed building in the Syrian town of Harem. The town is Idlib Province, on the border with Turkey, and is held by rebel forces.
Bodies in front of a hospital in Hatay, Turkey.
Abdulalim Muaini under the rubble next to the body of his wife, Esra, in the aftermath of a deadly earthquake in Hatay, Turkey.
Children collecting supplies from an aid distribution site in Turkey.
Resting in the Grand Mosque, a place of refuge after the earthquake, in the southeastern Turkish city of Diyarbakir.
A family sitting at a bonfire at a playground next to a collapsed building in Hatay, Turkey.
A rescue operation at a collapsed apartment building, in Hatay, Turkey.
Rescuers searched for survivors in Adana, Turkey.
Civilians searching for their relatives under a collapsed building in Kahramanmaras, Turkey.
Survivors were left with little refuge amid heavy snow in Malatya.
A man was pulled from the rubble in Malatya, Turkey.
Survivors sheltering in a tent in Hatay, Turkey.
Civilians search for their relatives in a collapsed building in Kahramanmaras, Turkey.
A mother searches for her son in the collapsed building in Kahramanmaras.
Emergency responders rescued a child buried in the rubble in the village of Qatma, Syria.
Rescue workers saved Vacit Amuri, 3, a girl from a Syrian family, from a collapsed building in Kahramanmaras, Turkey.
Smoke rising from burning containers at the port in Iskenderun, Turkey.
Aid distribution in Iskenderun, Turkey.
A severely damaged mosque in Malatya, Turkey.
The body of a child in the rubble in Jandaris, in the rebel-held part of Aleppo province, Syria.
Survivors in Hatay, Turkey.
The destruction in Hatay, Turkey.
Searching for survivors in Adana, Turkey.
Gathering around a bonfire in Kahramanmaras, Turkey.
Rescue teams searched through the night for survivors in Idlib, Syria.
An injured girl was helped from a badly damaged building in Jandaris, a town in Idlib, a rebel-held province in northwestern Syria.
Several buildings were reduced to rubble in Iskenderun, Turkey.
Mesut Hancer holding the hand of his 15-year-old daughter, Irmak, who died in the earthquake in Kahramanmaras, Turkey, on Monday.
Looking on as emergency teams searched for survivors and victims in the rubble of a building in Adana, Turkey.
Rescue teams searched for survivors in Sarmada, Syria.
Rescuers carried a girl from a collapsed building in Diyarbakir, Turkey.
Searching for survivors in Adana, Turkey.
An aftershock caused a damaged building to crumble in Jarabulus, Syria.
The earthquake seriously damaged Turkey’s historic Gaziantep Castle.
Mourning victims at a hospital in Atareb, in Aleppo Province, Syria.
Rescue workers pulled a boy from the rubble in Dana, in the Syrian province of Idlib.
A man and his injured child awaiting treatment at the Bab al-Hawa Hospital in Idlib Province, Syria.
Searching through the rubble in Aleppo, Syria.
Rescuing an injured man from a collapsed building in the town of Jandaris, Syria.
Bodies outside a morgue in Aleppo, Syria.
Residents gazing at a destroyed building in Adana, Turkey.
The Syrian rescue workers known as the White Helmets, who operate in areas outside government control, trying to extract a man from the rubble in Azaz, near the border with Turkey.
The earthquake severely damaged the historic Yeni Mosque in Malatya, Turkey.
A badly damaged building in Diyarbakir, Turkey.